Balasubramanian B, et al. - Researchers focused on the effectiveness as well as the safety of various total intravenous anesthesia used for pediatric magnetic resonance imaging (MRI). Participants were children of 1–7 years age (n = 88). A loading dose of dexmedetomidine 1 μg/kg over 10 min, ketamine 1 mg/kg, and propofol 1 mg/kg was received in sequence by participants undergoing MRI. For initiating the scan, the University of Michigan Sedation Scale (UMSS) of 3 was regarded as an acceptable level. If UMSS continued to be < 3, rescue ketamine 0.25–0.5 mg/kg was administered. UMSS = 4 or progressive drop in heart rate was noted in some children following the loading dose of drugs, so these children did not receive any infusion. Either dexmedetomidine (0.7 μg/kg/h) or propofol (3 mg/kg/h) infusion was received by the remaining children for maintenance. As rescue option, they used ketamine 0.25 mg/kg. Findings revealed the ability of dexmedetomidine 1μg/kg, ketamine 1 mg/kg, and propofol 1 mg/kg for offering good conditions for the start of MRI. The safety and the efficacy of dexmedetomidine at 0.7μg/kg/h and propofol at 3 mg/kg/h for maintenance were evident but faster recovery was offered by propofol.