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A national surveillance study of childhood epilepsy mortality in the UK and Ireland

European Journal of Neurology Jan 30, 2020

Abdel-Mannan O, et al. - Utilizing established active surveillance methodology designed by the British Paediatric Surveillance Unit, researchers conducted this prospective, population-based surveillance study to determine the UK and Ireland incidence of childhood epilepsy deaths and to report case demographics and clinical features. An overall annual incidence of 0.65 per 100,000 children aged < 16 years was recorded in 88 confirmed cases. Data reported that 25% of deaths were epilepsy-related [including sudden unexpected death in epilepsy (SUDEP)] and 75% of deaths were non-epilepsy-related. The authors discovered that death in children diagnosed with epilepsy occurs predominantly in ‘complicated epilepsy’ secondary to factors linked to neurodisability, consolidating previous information. In addition, SUDEP is an important cause of mortality from paediatric epilepsy that needs further attention. There is a strong need to better understand and reduce the number of deaths from epilepsy in children in the UK, and SUDEP national monitoring is needed for a better understanding of this entity in paediatric populations.
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