Tiegs AW, Tao X, Zhan Y, et al. - Via this prospective, blinded, multicenter, nonselection study, researchers investigated the predictive value of an aneuploid diagnosis with a targeted next-generation sequencing–based preimplantation genetic testing for aneuploidy (PGT-A) assay in prognosticating the failure of a successful delivery. Among 402 patients undergoing their first in vitro fertilization cycle without recurrent pregnancy loss, antral follicle count < 8, or body mass index ≥ 35 kg/m ², 484 single, frozen, blastocyst transfers were performed. The PGT-A aneuploid diagnosis clinical error rate of 0% was observed. Outcomes suggest a high prognostic value of the PGT-A assay for failure to deliver when an aneuploid result was obtained. Additionally, there was no detectable adverse impact of the trophectoderm biopsy on sustained implantation.