Shen J, Zhou H, Liu J, et al. - Researchers herein used the two-sample Mendelian randomization framework to develop a modifiable risk factors atlas of lung cancer. They considered 46 modifiable risk factors revealed in previous studies. They identified a significant correlation of higher socioeconomic status with a lower risk of lung cancer, including years of schooling, college or university degree, and household income. A significant connection with a higher risk of lung cancer was shown by factors such as cigarettes smoked per day, time spent watching TV, polyunsaturated fatty acids, docosapentaenoic acid, eicosapentaenoic acid, and arachidonic acid in blood. Serum vitamin A1, copper in blood, docosahexaenoic acid in blood, and body fat percentage, all were revealed as suggestive risk factors for lung cancer. This work affords the first Mendelian randomization evaluation of the causality between earlier documented risk factors and lung cancer risk. Consideration should be given to various changeable targets, concerning socioeconomic status, lifestyle, dietary, and obesity, for the development of primary prophylactic strategies for lung cancer.