Kemp JP, et al. - In 15-year-olds from the Avon Longitudinal Study of Parents and Children, researchers analyzed relationships between a metabolic screen focusing on fat metabolism and peripheral quantitative computed tomography (pQCT) measures of the mid-tibia. By proton nuclear magnetic resonance spectroscopy, metabolic profiles were made from blood samples gotten at the same time as pQCT scans from 1,121 patients. Only the correlation between citrate and BMD_C stayed below the Bonferroni-marked threshold after additional adjustment for height, fat, and lean mass. Citrate also exhibited a correlation with PC, strength strain index, and serum β-C-telopeptides of type I collagen (β-CTX). The above relations between citrate and BMD_C, PC, and strength strain index were no longer seen following the additional adjustment for β-CTX. Circulating levels of citrate were inversely correlated to BMD_C and positively related to PC, mirroring relationships with higher bone turnover in adolescents.