Wachinger C, et al. - Researchers sought to investigate genetic impacts on brain asymmetry by recognizing links between MRI-derived measures of asymmetry and candidate single-nucleotide polymorphisms (SNPs) that have been identified previously in genome-wide association studies for Alzheimer’s disease (AD) diagnosis and for brain subcortical volumes. They recognized SNPs in the genes TNKS and DLG2 to be associated with AD-related increases in shape asymmetry, since they have been linked to subcortical volumes of amygdala and putamen before, but not with Alzheimer’s pathology. This study provides original evidence on the biological underpinnings of brain asymmetry as a disease marker. Contralateral brain structures represent a unique, within-patient, reference element for disease and asymmetries and can provide a personalized measure of the accumulation of past disease processes.