Huynh-Le MP, et al. - Researchers evaluated the potential influence of a polygenic hazard score (PHS; a weighted sum of 54 SNP genotypes), previously validated for accurate prediction of age of onset of aggressive prostate cancer (PCa) and for better screening PSA performance, on individualized prostate cancer screening when applied to population data. Data analysis including information on age-specific PCa incidence was carried out for men aged 40-70 years from the UK (Cancer Research UK, 2013-2015). The data were fit to an exponential curve as a continuous model of age-specific PCa incidence. For specific percentiles of genetic risk (1, 5, 20, 50, 80, 95, and 99) they estimated annualized incidence rate curves by using hazard ratios calculated from ProtecT study data. They defined a risk-equivalent age by combining PHS with incidence data, when the risk of aggressive PCa in a man with given PHS percentile will be same as that of a typical man at age 50 years. With individualized estimates of risk-equivalent age for aggressive PCa, PCa screening may be informed by PHS.