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A genetic risk score and number of myopic parents independently predict myopia

Ophthalmic and Physiological Optics Dec 08, 2018

Mojarrad NG, et al. - Researchers investigated how a genetic risk score (GRS) influences the performance of predicting refractive error compared to knowing a child's number of myopic parents (NMP) alone. For this purpose, data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort study was retrospectively analyzed. Non-cycloplegic autorefraction was used to assess refractive error between age 7–15 longitudinally. They calculated a GRS for each child using genetic variants (n = 149) associated with refractive error from a Consortium for Refractive Error And Myopia (CREAM) genome-wide association study. Children at risk of myopia were better assessed via a GRS independently of knowing the NMP. This may be due to the fact that NMP captures information concerning environmental risk factors for myopia.
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