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A genetic risk score and number of myopic parents independently predict myopia

Ophthalmic and Physiological Optics Sep 10, 2018

Mojarrad NG, et al. - Authors assessed if a genetic risk score (GRS) could improve the prediction of refractive error vs knowing the number of a child's myopic parents (NMP) alone. They conducted a retrospective analysis of data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort study. The ability to detect children at risk of myopia independently of knowing the NMP improved with a GRS. Authors assumed this was due to information concerning environmental risk factors for myopia being captured by NMP. At ages 7 and 15 years, the performance was improved by the combined model.

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