Atan R, et al. - Assuming that high cytokine levels sustain the shock state in critically ill patients with acute kidney injury receiving vasopressors, researchers investigated if high cutoff hemofiltration attains better cytokine removal and impacts duration of shock and albumin losses among vasopressor-dependent patients with acute kidney injury who were admitted to the ICU. For this purpose, they compared continuous venovenous hemofiltration-high cutoff to continuous venovenous hemofiltration-standard in this single-center double-blind randomized controlled trial. In critically ill patients with acute kidney injury, no reduction in duration of vasopressor support or mortality nor change in albumin levels was evident in correlation with continuous venovenous hemofiltration-high cutoff vs with continuous venovenous hemofiltration-standard.