Mohammad J, et al. - In view of epidemiologic evidence reporting increased cardiovascular morbidity and mortality associated with both high dietary and serum phosphate in humans with normal renal function, researchers studied systemic hemodynamics in controlled phosphate intervention study. They randomized 20 young adults with normal renal function to high phosphate (regular diet plus 1 mmol/kg body wt per day of Na as neutral sodium phosphate) or low phosphate (regular diet plus lanthanum, 750 mg thrice/day, plus 0.7 mmol/kg body wt per day of Na as NaCl) for 11 weeks. Intramuscular injection of vitamin D3 (600,000 U) was given to all subjects after 6 weeks. Significantly increased systolic and diastolic BP (SBP and DBP), and pulse rate (PR) were reported in relation to increased phosphate intake (controlled for sodium). This impact was partially attributed to increased sympathoadrenergic activity.