Hanna AH, et al. - In this prospective randomized double-blinded clinical trial, zolpidem was compared to midazolam for pediatric preoperative anxiety. This investigation was based on the theory that impaired perception following oral zolpidem administration would suppress the development of anxiety. Participants were 80 pediatric patients with ASA class I-II, aged between 2 and 9 years, surgery >2 hours, and at least 23 hours postoperative admission. Researchers randomly administered 0.5 mg/kg midazolam or 0.25 mg/kg zolpidem, orally, to the participants. Between group difference in patient anxiety at the time of separation was assessed using the Modified Yale Preoperative Anxiety Scale. According to findings, anxiety scoring was similar between zolpidem, as dosed, and midazolam. With regard to mask acceptance scores, zolpidem was found to be inferior to midazolam.