Lin CH, et al. - In elderly patients with schizophrenia, researchers investigated the effectiveness of long-acting injectable antipsychotics (LAIs) vs oral antipsychotics (OAPs) on time to rehospitalization within 1 year of discharge, as well as other factors that may be correlated with time to rehospitalization and trends in LAI prescription rates over the study period. Under naturalistic conditions, they followed patients over 60 years of age with schizophrenia discharged between 2006 and 2017 for 1 year. LAIs and OAPs were compared regarding time to rehospitalization via survival analysis. Outcomes revealed that compared with OAPs, LAIs were better in preventing rehospitalization. The superior side-effect profile of second-generation LAIs vs the first-generation LAIs may explain the continuous increase in second-generation LAI prescription rate.