Fidler-Benaoudia MM, Oeffinger KC, Yasui Y, et al. - Since it is not clear whether late effect risks among childhood cancer survivors differ internationally, researchers compared late mortality in the North American Childhood Cancer Survivor Study (CCSS) and British Childhood Cancer Survivor Study (BCCSS). Using cumulative mortality probabilities and adjusted ratios of the standardized mortality ratio (RSMR), late mortality was evaluated among 49,822 5-year survivors of childhood cancer diagnosed before 15 years of age from 1970-1999 (CCSS n = 31,596; BCCSS n = 18,226). The results indicate that US survivors may have received more intensive regimens to achieve sustainable remission and cure, but there was a higher risk of death from late effects at the expense of this strategy. Although the clinical significance of these variations is uncertain, the findings provide valuable evidence to better discuss the management of late effects.