Schwalm JD, McCready T, Lopez-Jaramillo P, et al. - Through an open, community-based, cluster-randomized controlled trial comprising 1,371 individuals with new or poorly controlled hypertension from 30 communities in Colombia and Malaysia, experts tested whether a model of care including non-physician health workers (NPHWs), primary care physicians, family, and the provision of efficient medications, could substantially decrease cardiovascular disease risk. The decrease in the Framingham Risk Score for 10-year cardiovascular disease risk was −6·40% and −11·17% in the control group and intervention group, respectively, with a variation of change of −4·78%. An absolute 11·45 mm Hg greater decrease in systolic blood pressure, and a 0·41 mmol/L decline in LDL with the intervention group was noted. Alteration in blood pressure control status (< 140 mm Hg) was 69% in the intervention group vs 30% in the control group. No safety concerns with the intervention were observed. In conclusion, a comprehensive model of care led by NPHWs, including primary care physicians and family that was notified by local context, substantially enhanced blood pressure control and cardiovascular disease risk. This approach is efficient, practical, and has the potential to substantially decrease cardiovascular disease in comparison with current approaches that are typically physician based.