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A case-control study to identify predictors of 14-day mortality following carbapenem-resistant Acinetobacter baumannii bacteraemia

Clinical Microbiology and Infection Mar 03, 2019

Nutman A, et al. - Since carbapenem-resistant Acinetobacter baumannii (CRAB) is becomming more common, researchers examined patients with CRAB bacteraemia to identify clinical and microbiological predictors of 14-day mortality. They included all adult patients in one Israeli hospital with CRAB on blood culture between July 2008 and June 2011 in this case-control study. As per findings, severity of illness, independence in activities of daily living (ADL) on admission, surgery before bacteraemia, and clone group were identified as the independent predictors of 14-day mortality. They identified active antibiotic treatment as protective in the multivariate Cox model using a propensity score to adjust for SOFA, clone, ADL, and surgery. Heterogeneous results in previous studies of mortality following CRAB infection may partly be due to the differences in virulence between CRAB clones.

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