• Profile
Close

A case-control study of trace-element status and lung cancer in Appalachian Kentucky

PLoS Neglected Tropical Diseases Mar 14, 2019

Unrine JM, et al. - Researchers examined 520 Appalachian Kentucky (App KY) individuals for a possible association between lung cancer incidence and trace-element exposure using toenail and drinking water trace element concentrations. Of these, 367 patients provided toenail samples. They also assessed the utility of fingernails as a surrogate for toenails when patients are unable to provide toenail samples. As per findings, cancer cases did not display higher trace element concentrations (Al, As, Cr, Mn, Co, Fe, Ni, Cu, Se, and Pb) than controls, other than Zn where concentrations were slightly higher in cases. In univariate logistic regression models, lower concentrations of several elements (Al, Mn, Cr, and Se) were more frequently noted in lung cancer cases, although only Mn was significant in multivariate models which controlled for confounding factors. While there appeared a positive correlation of drinking water concentrations of Al, Cr, and Co with cancer incidence in univariate models, only Co remained notable in multivariate models. As toenail concentrations could not be consistently predicted using fingernail concentrations, they do not support using fingernails as surrogates for toenails in future studies.

Full text available Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
  • Exclusive Write-ups & Webinars by KOLs

  • Nonloggedininfinity icon
    Daily Quiz by specialty
  • Nonloggedinlock icon
    Paid Market Research Surveys
  • Case discussions, News & Journals' summaries
Sign-up / Log In
x
M3 app logo
Choose easy access to M3 India from your mobile!


M3 instruc arrow
Add M3 India to your Home screen
Tap  Chrome menu  and select "Add to Home screen" to pin the M3 India App to your Home screen
Okay