Lischka J, Schanzer A, Hojreh A, et al. - In the present study, the researchers examined novel biomarkers for non‐alcoholic fatty liver disease (NAFLD) and developed a score that predicts liver fat in youth with severe obesity. Clinically thoroughly characterized including MRI‐derived proton density fat fraction (MRI‐PDFF), amino acids and acylcarnitines were measured by HPLC‐MS from a population with a BMI > 97th percentile aged 9‐19 years (n = 68). Higher levels of plasma branched‐chain amino acids (BCAA) were determined in children with NAFLD. BCAAs can play a key role in the relation between obesity and other metabolic pathways. In the future, a BCAA-based metabolic score could be used to predict the severity of steatosis in high-risk children and adolescents, and it could be a viable alternative to advanced approaches like MRI or biopsy.