Schutte S, et al. - In this double-blind, parallel trial, researchers studied the potential benefits of whole-grain wheat (WGW) consumption vs refined wheat (RW) consumption on liver health and associated parameters. For this investigation, 50 overweight men and postmenopausal women (aged 45-70 years) were randomly allocated to a 12-week intervention with either WGW (98 g/d) or RW (98 g/d) products. Findings revealed that the RW or WGW intervention did not affect fasting plasma cholesterol, triglycerides, nonesterified fatty acids, and insulin. The data presented in this work showed that a 12-week RW intervention increases liver fat and could contribute to the development of nonalcoholic fatty liver disease, while a 12-week 98-g/d WGW intervention prevents a significant increase in liver fat. Investigators found that including feasible doses of WGW in the diet at the expense of RW maintains liver health.