Utzschneider KM, Tripputi MT, Kozedub A, et al. - In this cross‐sectional analysis of baseline data from the Restoring Insulin Secretion (RISE) Study, researchers sought to compare model‐derived measures of β‐cell function between youth and adults with either impaired glucose tolerance (IGT) or type 2 diabetes to assess whether a β‐cell defect distinguishes these age groups. Youth (54 Y‐IGT, 33 Y‐D) and adults (250 A‐IGT, 104 A‐D) undergone 3‐hour oral glucose tolerance tests for modeling of insulin secretion rates (ISRs), glucose sensitivity, and rate sensitivity. Despite a similar body mass index, the youth had lower insulin sensitivity. Model‐derived measures of β‐cell function provide further insight into the pathophysiology of type 2 diabetes in youth with higher ISRs and β‐cell secretion more responsive to glucose in youth compared with adults even after adjusting for insulin sensitivity differences. It is unclear if these results in youth reflect β‐cells that are healthier or whether this is a defect that leads to more rapid loss of function.