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5-year overall survival in patients with lung cancer eligible or ineligible for screening according to US Preventive Services Task Force criteria: A prospective, observational cohort study

The Lancet Oncology Jul 03, 2019

Luo YH, et al. - Given their previous work demonstrating that two-thirds of newly diagnosed patients with lung cancer do not meet the criteria under the US Preventive Services Task Force (USPSTF) recommendation for lung cancer screening, researchers examined survival outcomes in long-term quitters (≥15 years since quitting) and a younger age group (age 50–54 years), both of whom usually don’t meet the criteria. Patients aged 50–80 years with lung cancer and a smoking history of 30 pack-years or more were studied in this prospective, observational cohort study; they included both current smokers and former smokers who quit within the past 30 years. They identified and followed up 8,739 patients with lung cancer. As per findings, risk of death for patients with lung cancer who quit 15 or more years before diagnosis and for those who are up to 5 years younger than the age cutoff recommended for screening, but otherwise meet USPSTF criteria, were similar to the risk observed for those individuals who meet all USPSTF criteria. Screening may benefit the individuals in both subgroups, as expansion of USPSTF screening criteria to include these subgroups could allow earlier detection of lung cancer and enhanced survival outcomes.

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