UW treats first participant in trial of stem-cell therapy for heart failure
University of Wisconsin-Madison Health News Apr 21, 2017
A research team at University of Wisconsin School of Medicine and Public Health has treated its first patient in an innovative clinical trial using stem cells for the treatment of heart failure that develops after a heart attack.
The trial is taking place at University Hospital, one of three sites nationwide currently enrolling participants. The investigational CardiAMP therapy is designed to deliver a high dose of a patientÂs own bone–marrow cells directly to the point of cardiac injury to potentially stimulate the bodyÂs natural healing response.
The patient experience with the trial begins with a cell–potency screening test. Patients who qualify for therapy are scheduled for a bone–marrow aspiration. The bone marrow is then processed on–site and subsequently delivered directly to the damaged regions in a patientÂs heart in a minimally invasive procedure.
ÂPatients living with heart failure experience a variety of negative symptoms that can greatly impact their day–to–day life, said UW Health cardiologist Dr. Amish Raval, associate professor of medicine and one of the principal investigators for the trial. ÂBy being at the forefront of research for this debilitating condition, we look forward to studying the potential of this cell therapy to impact a patientÂs exercise capacity and quality of life.Â
The primary outcome to be measured is the change in distance during a six–minute walk 12 months after the initial baseline measurement.
The CardiAMP Heart Failure Trial is a phase III study of up to 260 patients at up to 40 centers nationwide. Phase III trials are conducted to measure effectiveness of the intervention, monitor side effects and gather information for future use of the procedure. Study subjects must be diagnosed with New York Heart Association (NYHA) Class II or III heart failure as a result of a previous heart attack.
Information about eligibility or enrollment in the trial is available at www.clinicaltrials.gov, or through a cardiologist.
The trial is funded by Biocardia, Inc., which developed the potential therapy.
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The trial is taking place at University Hospital, one of three sites nationwide currently enrolling participants. The investigational CardiAMP therapy is designed to deliver a high dose of a patientÂs own bone–marrow cells directly to the point of cardiac injury to potentially stimulate the bodyÂs natural healing response.
The patient experience with the trial begins with a cell–potency screening test. Patients who qualify for therapy are scheduled for a bone–marrow aspiration. The bone marrow is then processed on–site and subsequently delivered directly to the damaged regions in a patientÂs heart in a minimally invasive procedure.
ÂPatients living with heart failure experience a variety of negative symptoms that can greatly impact their day–to–day life, said UW Health cardiologist Dr. Amish Raval, associate professor of medicine and one of the principal investigators for the trial. ÂBy being at the forefront of research for this debilitating condition, we look forward to studying the potential of this cell therapy to impact a patientÂs exercise capacity and quality of life.Â
The primary outcome to be measured is the change in distance during a six–minute walk 12 months after the initial baseline measurement.
The CardiAMP Heart Failure Trial is a phase III study of up to 260 patients at up to 40 centers nationwide. Phase III trials are conducted to measure effectiveness of the intervention, monitor side effects and gather information for future use of the procedure. Study subjects must be diagnosed with New York Heart Association (NYHA) Class II or III heart failure as a result of a previous heart attack.
Information about eligibility or enrollment in the trial is available at www.clinicaltrials.gov, or through a cardiologist.
The trial is funded by Biocardia, Inc., which developed the potential therapy.
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