New technique could increase success rate, life span of implantable devices
Purdue University Research news Jun 12, 2017
A new technique being developed at Purdue University could provide patients who require implantable catheters in the treatment of neurological and other disorders with a reliable and self–clearing catheter that could eliminate the need for additional surgery to replace failing devices.
ÂImplantable catheters are used to treat a number of neurological and cardiac disorders by either diverting excess fluid or for delivering drugs. Specifically, catheters can greatly benefit patients with hydrocephalus, said Hyowon ÂHugh Lee, an assistant professor in PurdueÂs Weldon School of Biomedical Engineering and developer of the technology. ÂOver 1 million people in the U.S. suffer from hydrocephalus, and one to two newborns develop the disorder every 1,000 births. Patients can also acquire hydrocephalus later in life from traumatic brain injury or hemorrhagic stroke. Hydrocephalus can cause an enlarged head in children and many other life–altering physical, behavioral and cognitive symptoms in children and adults alike.Â
Lee said existing implantable catheters have a high failure rate that requires additional surgery or intervention.
ÂWhen a catheter is implanted, the bodyÂs natural reaction is to protect itself against the foreign material by forming a sheath around it. Biofouling materials including bacteria, blood and inflammatory cells, and other tissue quickly cover the device, often blocking the catheterÂs inlet pores leading to premature device failure, he said.
The technology being developed by Lee is a smart self–clearing catheter in the form of microscale devices on a paper–thin film that can be assembled into existing catheters. The technology has tiny magnetic elements on top of micromechanical devices that uses magnetic force to remove biomaterials that attach to the catheter. A video about the technology is available at https://youtu.be/ooCUSTkPGfk.
ÂWhen you have a compass and you put a magnet nearby it, you can make the needle move. There are a couple different ways for magnetic actuation, but one is to make it torque like a seesaw, Lee said. ÂThatÂs what we essentially do with our device integrated into catheters. The micro–device is fixed at an anchor point, and we apply magnetic field from outside the body. By using time–varying magnetic field, changing its magnitude or turning it on or off, you create dynamic movement and mechanical vibration at the pore to be able to remove the obstructive biomaterials. The magnetic approach is ideal for this application because it generates a large amount of force and can be done without an integrated circuit or power source. This makes it much simpler and reduces the burden of hermetic packaging for implantation. Lee said the technology is currently undergoing further testing.
ÂWe have demonstrated the efficacy of the device with providing enough force to be able to remove the different types of biomaterial, Lee said. ÂWe are currently testing these self–clearing catheters for in–vitro and in–vivo evaluations and are actively working on new devices for other types of indwelling catheter applications.Â
A similar device is also in the works for better treatment of glaucoma, Lee added.
ÂGlaucoma patients have similar problems with pressure buildup inside their eye. More patients are undergoing surgical procedures to implant drainage devices to remove excess vitreous humor and lower intraocular pressure, he said. ÂWe are creating even smaller magnetic micro–actuators that go into the glaucoma drainage device tubes. This will address the issue of biomaterial obstruction that these devices face as well.Â
The Purdue Research FoundationÂs Office of Technology Commercialization has patented the technology and it is available for license. Additional images of the researcher and technology are available at https://goo.gl/DkvTct.
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ÂImplantable catheters are used to treat a number of neurological and cardiac disorders by either diverting excess fluid or for delivering drugs. Specifically, catheters can greatly benefit patients with hydrocephalus, said Hyowon ÂHugh Lee, an assistant professor in PurdueÂs Weldon School of Biomedical Engineering and developer of the technology. ÂOver 1 million people in the U.S. suffer from hydrocephalus, and one to two newborns develop the disorder every 1,000 births. Patients can also acquire hydrocephalus later in life from traumatic brain injury or hemorrhagic stroke. Hydrocephalus can cause an enlarged head in children and many other life–altering physical, behavioral and cognitive symptoms in children and adults alike.Â
Lee said existing implantable catheters have a high failure rate that requires additional surgery or intervention.
ÂWhen a catheter is implanted, the bodyÂs natural reaction is to protect itself against the foreign material by forming a sheath around it. Biofouling materials including bacteria, blood and inflammatory cells, and other tissue quickly cover the device, often blocking the catheterÂs inlet pores leading to premature device failure, he said.
The technology being developed by Lee is a smart self–clearing catheter in the form of microscale devices on a paper–thin film that can be assembled into existing catheters. The technology has tiny magnetic elements on top of micromechanical devices that uses magnetic force to remove biomaterials that attach to the catheter. A video about the technology is available at https://youtu.be/ooCUSTkPGfk.
ÂWhen you have a compass and you put a magnet nearby it, you can make the needle move. There are a couple different ways for magnetic actuation, but one is to make it torque like a seesaw, Lee said. ÂThatÂs what we essentially do with our device integrated into catheters. The micro–device is fixed at an anchor point, and we apply magnetic field from outside the body. By using time–varying magnetic field, changing its magnitude or turning it on or off, you create dynamic movement and mechanical vibration at the pore to be able to remove the obstructive biomaterials. The magnetic approach is ideal for this application because it generates a large amount of force and can be done without an integrated circuit or power source. This makes it much simpler and reduces the burden of hermetic packaging for implantation. Lee said the technology is currently undergoing further testing.
ÂWe have demonstrated the efficacy of the device with providing enough force to be able to remove the different types of biomaterial, Lee said. ÂWe are currently testing these self–clearing catheters for in–vitro and in–vivo evaluations and are actively working on new devices for other types of indwelling catheter applications.Â
A similar device is also in the works for better treatment of glaucoma, Lee added.
ÂGlaucoma patients have similar problems with pressure buildup inside their eye. More patients are undergoing surgical procedures to implant drainage devices to remove excess vitreous humor and lower intraocular pressure, he said. ÂWe are creating even smaller magnetic micro–actuators that go into the glaucoma drainage device tubes. This will address the issue of biomaterial obstruction that these devices face as well.Â
The Purdue Research FoundationÂs Office of Technology Commercialization has patented the technology and it is available for license. Additional images of the researcher and technology are available at https://goo.gl/DkvTct.
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