When temperatures reach extremes of an average daily temperature of 109 degrees Fahrenheit, the number of deaths from cardiovascular disease may double or triple. Researchers note that these findings raise concerns that traditionally hot regions may be especially vulnerable to heat-related cardiovascular deaths, according to new research published today in Circulation, the flagship journal of the American Heart Association.

The highest temperature on earth in the last 76 years, 129 degrees Fahrenheit, was recently recorded in Kuwait. Given the consistently high temperatures in Kuwait (average ambient temperature 82.2 degrees Fahrenheit), researchers examined the relationship between temperature and more than 15,000 cardiovascular-related deaths in the country. All death certificates in Kuwait from 2010 to 2016 that cited “any cardiovascular cause” for individuals ages 15 and older were reviewed for this study.

Compared to the number of deaths on days with the lowest mortality temperature (average daily temperature of 94.5 degrees Fahrenheit, when the fewest people died), when the 24-hour average temperature was extreme (109 degrees Fahrenheit or higher), the investigators found:

  • Overall, a 3-times greater risk of dying from any cardiovascular cause;
  • Men were more affected by the extreme temperatures, experiencing a 3.5 times higher death rate;
  • The death rate among women was nearly 2.5 higher;
  • Working-age people (ages 15-64 years) had a death rate 3.8 times higher; and
  • The death rate was just over 2-times higher for people 65 and older.  

To examine the effects of temperature on its own, the investigators adjusted for other environmental factors such as air pollution and humidity. Higher temperatures affected both genders and all ages differently.

“While cardiologists and other medical doctors have rightly focused on traditional risk factors, such as diet, blood pressure and tobacco use, climate change may exacerbate the burden of cardiovascular mortality, especially in very hot regions of the world,” said Barrak Alahmad, MBChB, MPH, a mission scholar from Kuwait University and a PhD. candidate in environmental health at the Harvard T.H. Chan School of Public Health in Boston.

When core body temperature increases, the human body tries to cool itself by shifting blood from the organs to underneath the skin. This shift causes the heart to pump more blood, putting it under significantly more stress. A collaborative group of cardiologists, environmental health specialists, and epidemiologists hypothesized that increasing temperatures in hotter regions of the world could lead to increased CVD death due to extreme heat’s effects on the body.

“The warming of our planet is not evenly distributed. Regions that are inherently hot, like Kuwait and the Arabian Peninsula, are witnessing soaring temperatures unlike ever before. We are sounding the alarm that populations in this part of the world could be at higher risk of dying from cardiovascular causes due to heat,” said Alahmad. “Although we cannot conclude it from this analysis, men and working-age people may have been at greater increased risk because of spending more time outside. We need to explore this relationship further and consider serious preventive strategies that could reduce the impact of rising temperatures on our health.”

The study was limited by only having information on any cardiovascular cause of death, so it is not known whether any specific type of heart problem is more susceptible to the influence of extreme heat. Although the researchers found a strong association between extremely high temperatures and increased cardiovascular deaths, further research is needed to establish a cause and effect relationship.

Co-authors are Haitham Khraishah, M.D.; Ahmed F. Shakarchi, M.D., M.P.H.; Mazen Albaghdadi, M.D.; Sanjay Rajogopalan, M.D.; Petros Koutrakis, Ph.D.; and Farouc A. Jaffer, M.D., Ph.D.

The analysis was funded by the United States Environmental Protection Agency and the Kuwait Foundation for the Advancement of Sciences.

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