Anti–inflammatory diets – which tend to be high in vegetables, fruits, fish and whole grains – could boost bone health and prevent fractures in some women, a new study suggests.

Researchers examined data from the landmark Women’s Health Initiative to compare levels of inflammatory elements in the diet to bone mineral density and fractures and found new associations between food and bone health.

The study, led by Tonya Orchard, an assistant professor of human nutrition at The Ohio State University, appeared in the Journal of Bone and Mineral Research.

Women with the least–inflammatory diets (based on a scoring system called the Dietary Inflammatory Index) lost less bone density during the six–year follow–up period than their peers with the most–inflammatory diets. This was despite the fact that they started off with lower bone density overall.

Furthermore, diets with low inflammatory potential appeared to correspond to lower risk of hip fracture among one subgroup of the study – post–menopausal white women younger than 63.

The findings suggest that women’s bone health could benefit when they choose a diet higher in beneficial fats, plants and whole grains, said Orchard, who is part of Ohio State’s Food Innovation Center.

Because the study was observational, it’s not possible to definitively link dietary patterns and bone health and fracture outcomes.

Previous studies have connected high levels of inflammatory markers in the blood to bone loss and to fractures in older women and men, which prompted Orchard and her colleagues to wonder what they’d find if they took one more step back – to the dietary choices that contribute to inflammation in the body.

The Dietary Inflammatory Index – developed to assess the quality of diet from maximally to minimally inflammatory based on nutrients consumed – helped them accomplish that. Dietary information as well as data on bone density and fracture were collected from a large group of the participants in the Women’s Health Initiative, the largest study of postmenopausal women’s health undertaken in U.S. history.

Participants in the WHI were 50 to 79 when they enrolled in the study of prevention and control of common diseases impacting older women. Enrollment ran from 1993 to 1998.

For the new analysis the research team looked at dietary data from 160,191 women and assigned inflammation scores based on 32 food components that the women reported consuming in the three months prior to their enrollment.

The researchers used bone–mineral–density data from a subset of 10,290 women. Fracture data was collected for the entire study group.

Orchard and her colleagues found a correlation only between high–inflammatory diets and fracture in younger white women in the study. Higher scores were associated with an almost 50 percent larger risk of hip fracture in Caucasian women younger than 63, compared with the risk for women in the group with the lowest inflammatory scores.

But in the study group overall, more–inflammatory diets were not linked to fracture and – in fact – the researchers found a modestly lower risk of lower–arm and total fracture in women with the highest dietary inflammation scores. One possible explanation included in the study: The women with lower inflammation scores were more physically active as a group and therefore were at a slightly greater risk of falls.

Women with the least–inflammatory diets had lower bone mineral density overall at the start of the study, but lost less bone than their high–inflammation peers, the researchers found. The lower bone density to start could be because women with healthier diets are more likely to be of a smaller build, Orchard said.