Determining an individual's blood group based on genetic tests instead of merely traditional blood tests can provide a better picture of the risk of cardiovascular diseases.

If a patient has two genetic variants of A, B or AB, the risk is twice as high compared with if one is O. This is the finding of a new study from Uppsala University using data from UK Biobank.

"There is a large difference in the risk for blood clots, depending on if someone has one or two genetic variants of the blood groups A, AB or B. Simply put, there is twice the risk of suffering from blood clots if you have two variants of A or B rather than just one," says Julia Hoglund, a doctoral student at the Department of Immunology, Genetics and Pathology at Uppsala University and the study's first author.

An individual can have one of four blood groups: A, B, AB or O. An individual's blood group is critical, for example, when receiving blood transfusions.

Recently, it has been shown that the blood group also plays a role in how a person is infected by viruses and bacteria and even in the occurrence of cardiovascular diseases and cancer.

The study now being published shows that the genetic variants an individual receives from each of their parents also influence the risk of disease. The study is based on data from 500,000 subjects included in the population study UK Biobank. The researchers have conducted a more in-depth analysis of the genetics behind blood groups.

Like previous research, this study shows that individuals with blood group O are at a lower risk of cardiovascular diseases, such as blood clots, than those that have other blood groups. But by genetically analysing the blood groups rather than using traditional blood analysis, which is done using antibody tests, the researchers could determine which genetic variant a person had from each parent.

This can be significant in identifying diseases since an individual with blood group A can have either two genetic variants for A or one for A and one for O.

"This is not detected in a regular blood test since both A and B mask the O gene. A person's genetic variants play a big role in the risk of cardiovascular diseases. If this was the standard method used with patients, it would significantly improve the ability to find high-risk patients," says Hoglund.

Another finding from the study is that the researchers could see that the levels of multiple proteins differed between individuals with different blood groups.

The clearest example of this was proteins that help the blood to coagulate. The same blood groups that increase the risk of blood clots also had increased levels of proteins that are important for the coagulation of blood.

"Our findings show that by making it standard to determine the patient's blood group and the blood group's genetics, we would be able to discover and begin treating diseases at an early stage, which can prevent or delay serious complications."