Five-year data from the phase Ib KEYNOTE-001 clinical trial show that pembrolizumab (Keytruda) was safe and effective and substantially increased overall survival for advanced non-small cell lung cancer (aNSCLC).

Specifically, 23.2% of people who had not previously been treated with chemotherapy and 15.5% of previously-treated patients were alive after five years, with the greatest benefit observed in patients with higher PD-L1 expression. This represents a marked improvement over 5-year survival rates from the pre-immunotherapy era, which averaged 5.5% for aNSCLC. This is the longest follow-up study to date of people with aNSCLC treated with pembrolizumab, according to the researchers.

“The uniformly negative outlook that has been associated with a diagnosis of advanced non-small cell lung cancer is certainly no longer appropriate,” said lead study author Edward B. Garon, MD, MS, Associate Professor of Medicine at UCLA, Los Angeles, CA. “The fact that we have patients on this trial that are still alive after 7 years is quite remarkable. We also have evidence that most patients who are doing well after 2 years on pembrolizumab live for 5 years or more.”

Pembrolizumab binds to a protein on the surface of T cells called PD-1. PD-1 binds to ligands including PD-L1, inhibiting an immune response. By blocking PD-1, pembrolizumab activates T cells to attack tumor cells.

Pembrolizumab was first approved by the U.S. Food and Drug Administration for advanced melanoma in September 2014 and in aNSCLC in October 2015. Subsequently, in October 2016, pembrolizumab was approved as a first-line treatment for aNSCLC tumors that do not have EGFR or ALK gene mutations but that express PD-L1 on 50% or more of their cells.

Most recently, in April of this year, pembrolizumab received an expanded approval for front-line treatment of patients with stage III NSCLC who could not have the tumors surgically removed or irradiated, or aNSCLC with PD-L1 expression levels over 1% and no EGFR or ALK gene mutations.

About the Study
In 2011, when KEYNOTE-001 began enrollment, immunotherapy treatments were not widely available, so most participants had previously been treated with systemic medicines, or targeted therapies. There were 550 people with aNSCLC in the trial, including 101 patients who had not previously received any treatment and 449 patients who had received prior treatment. All patients received 2 mg/kg of their body weight of pembrolizumab every 3 weeks or 10 mg/kg every two or three weeks. In recent years, however, the protocol was changed to a single dose of 200 mg regardless of body weight every 3 weeks, the typical regimen in clinical practice.

Next Steps 
Dr. Garon noted that the researchers will try refining their understanding of which patients received the most benefit from pembrolizumab as well as identifying impediments that prevent the immune system from destroying tumors so that these mechanisms could also be combatted. The investigators hope to explore possible combination therapies of pembrolizumab with conventional or other immunotherapies.

This study received funding from Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA.

This article is a news release from 2019 ASCO Annual Meeting. Read the original here.