Current smokers and people with chronic obstructive pulmonary disease (COPD) have an increased risk of severe complications and higher mortality with COVID-19 infection, according to a new study.
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The study was published in the open-access journal PLOS ONE by Jaber Alqahtani of University College London, UK, and colleagues. COPD is a common, persistent dysfunction of the lung associated with a limitation in airflow.
An estimated 251 million people worldwide are affected by COPD. Given the effects of the SARS-CoV-2 coronavirus on respiratory function, the authors of the present study sought to understand the prevalence and the effects of COPD in COVID-19 patients.
In the new study, researchers systematically searched databases of scientific literature to find existing publications on the epidemiological, clinical characteristics and features of COVID-19 and the prevalence of COPD in COVID-19 patients. 123 potentially relevant papers were narrowed to 15 that met all quality and inclusion guidelines. The included studies had a total of 2473 confirmed COVID-19 patients. 58 (2.3%) of those patients also had COPD while 221 (9 percent) were smokers.
Critically ill COVID-19 patients with COPD had a 63 percent risk of severe disease and a 60 percent risk of mortality while critically ill patients without COPD had only a 33.4 percent risk of severe disease (RR 1.88, 95 percent CI 1.4-2.4) and 55 percent risk of mortality (RR 1.1, 95 percent CI 0.6-1.8). In addition, current smokers were 1.45 times more likely to have severe complications compared to former and never smokers (95 percent CI 1.03-2.04). The study was not able to examine whether there was an association between the frequency of COPD exacerbations, or severity of COPD, with COVID-19 outcomes or complications.
The results are limited by the fact that few studies were available to review, as well as the diverse locations, settings, and designs of the included studies. The authors add: "Despite the low prevalence of COPD and smoking in COVID-19 cases, COPD and current smokers were associated with greater COVID-19 severity and mortality."
