Hui H, et al. - The prognostic power of zinc-finger protein 418 (ZNF418) in gastric cancer (GC) and its potential role in GC development and progression were investigated. Using human microarray, an aggregate of 10 GC patients’ individual plasmas were collected and screened for dysregulated mRNA. ZNF418 was found to be significantly downregulated in IIIA–IV stage GC patients compared to IA–IIA stage GC patients among these dysregulated mRNAs. The authors discovered that ZNF418 was first identified to be significantly downregulated in GC. They suggested that ZNF418 could serve as a novel biomarker for GC and was involved in GC development.