Teixeira LR, Almeida LY, Silva RN, et al. - Since M2 macrophages are frequently identified in oral squamous cell carcinoma (OSCC), which, influenced by hypoxic conditions, appear to have high angiogenesis-inducing capacity, researchers analyzed the impacts of immunosenescence on tumor-associated macrophages and angiogenesis in OSC. They divided 57 OSCCs into three groups (I: <40 years [n = 17]; II: 40-65 years [n = 20]; III: >65 years [n = 20]). No significant association was found between macrophage and angiogenic markers. A comparable TAM and angiogenesis profile indicates the involvement of other mechanisms in young and elderly OSCC patients, rather than immunosenescence.