Lamparello AJ, et al. - Researchers investigated the impact of aging accompanied alterations in immune functions on levels of circulating inflammatory mediators and network expression after severe trauma. For this purpose, they compared cohorts of severely injured young and aged adults in terms of time-dependent changes in the levels of an extensive biomarker panel. As per findings, young and aged trauma patients display differences in the early inflammatory networks which are not simply a suppression of pro-inflammatory responses in the aged, but are characterized by a major shift in the mediator profile patterns with high levels of CXC chemokines in the aged. They observed significantly higher injury severity score [ISS] among the young group which was associated with higher circulating levels of 18 inflammatory mediators from admission to day 7. The aged group displayed higher levels of C-X-C motif chemokine 10/interferon gamma-induced protein 10 (CXCL10/IP-10) and chemokine ligand 9/monokine induced by gamma interferon (CXCL9/MIG).