Yoon CW, et al. - In young patients with ischemic stroke, researchers assessed the results of a panel for systemic vasculitis as a screening test. Consecutive patients (aged 18–45 years) with ischemic stroke between January 2010 and December 2017 were involved, and all of them had screening tests for systemic vasculitis including rheumatoid factor, antinuclear antibody, antineutrophil cytoplasmic antibodies, anticardiolipin antibody, lupus anticoagulant, antiphospholipid antibody, anti-DNA antibody, and anti-Ro/SSA and La/SSB antibodies. Of 198 patients, only 4 (2.0%) were diagnosed with systemic vasculitis, 2 with systemic lupus erythematosus, 1 with Sjogren’s syndrome, and 1 with Churg-Strauss syndrome. Putting every young ischemic stroke patient through vasculitis panel screening does not yield great outcomes unless a vasculitic process is suspected based on other systemic symptoms or signs of vasculitis. The screening of people with clinical signs should be targeted.