Walters E, et al. – This work was designed to assess the diagnostic utility of stool Xpert MTB/RIF (Xpert) compared with bacteriologic confirmation (combination of Xpert and culture of respiratory samples). Findings suggested that stool Xpert can rapidly confirm Tuberculosis (TB) in children who present with radiologic findings suggestive of severe TB. They suggest using Xpert on stool samples to improve access to rapid diagnostic confirmation and appropriate treatment in resource–limited settings where children frequently present with advanced disease.