Sacco A, et al. - In a contingency model as part of routine care, researchers assessed patient choices and uptake of non-invasive prenatal testing (NIPT) for aneuploidy screening offered. Data for all women with a singleton pregnancy attending for routine first-trimester screening over an 18-month period were retrospectively reviewed. Of the 9,342 women attending an ultrasound scan for the first trimester, 7,939 women were involved in this investigation. Of these, 352 had a high-chance Trisomy 21 screening result, and 291 chose NIPT. As the likelihood of trisomy 21 increased, the proportion of women opting for NIPT decreased: uptake was 93.2%, 90.0%, 77.1% and 47.2% for women with a chance of 1:100–150, 1:50–99, 1:10–49 and > 1:10, respectively. In a non-research National Health Service setting, the introduction of NIPT testing in a contingency model has a high uptake; the uptake rate is linked to the combined test risk outcome.