DeMeo DL, et al. – Investigators examined age-associated biological sex differences across a range of chronic obstructive pulmonary disease (COPD) severities. Study participants included 4,484 current and former smokers with COPD from the Genetic Epidemiology of COPD cohort. They used regression modeling to evaluate the link between age, sex, disease severity, and contributing factors of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification system (symptoms, exacerbation risk, airflow limitation). Women, especially younger women, were found to experience a significant symptom burden of COPD, including a greater likelihood of more severe dyspnea, airflow limitation, greater risk for exacerbations, and categorization in GOLD groups B and D, vs men with COPD. These differences, however, were less pronounced in older women with COPD.