Wu J, et al. - Researchers investigated the prognostic value of Wolf–Hirschhorn syndrome candidate 1 (WHSC1) in cervical cancer and examined how WHSC1 influence proliferation, migration, and invasion of cervical cancer cells and angiogenesis in human umbilical vein endothelial cells (HUVECs). Cervical cancer samples were evaluated using immunohistochemistry, real-time quantitative PCR, and Western blot, for the expression levels of WHSC1 and relevant cell lines. The viability and migration of C33A cells were investigated via Cell Counting Kit-8 and transwell assays, in vitro, and the effect of WHSC1 on angiogenesis in HUVECs was studied using a tube formation assay. As per outcomes, in cervical cancer, WHSC1 is suggested to be a poor prognostic indicator and a potential novel therapeutic target. In addition, a possible role of WHSC1 in the regulation of cervical cancer progression via the endothelial nitric oxide synthase signaling pathway was suggested.