Tran TX, et al. - In this study, for the first time, researchers examined an invasive N. meningitidis isolate from a military unit in Vietnam using whole-genome sequencing, for key genetic and epidemiological features. They identified high levels of resistance to chloramphenicol and diminished susceptibility to ampicillin and rifampicin in the susceptibility testing of the isolate. They assembled a draft genome of ~ 2.1 Mb, containing 2451 protein-coding sequences, 49 tRNAs and 3 rRNAs. Identification of 15 coding sequences sharing ≥ 84% identity with known antibiotic resistance genes was done. Abundant repetitive DNAs and two prophages were revealed in genome analysis. In epidemiological typing, they recognized newly described sequence type, antigenic finetype and Bexsero Antigen Sequence Typing (BAST). Neither Bexsero nor Trumenba covered the BAST profile. Findings thus suggest the utility of whole genome sequencing analysis for epidemiological and antibiotic resistance studies and surveillance of invasive meningococcal disease in Vietnam.