Suntharalingam S, et al. - The radiation dose and image quality of a whole-body low-dose CT (WBLDCT) were investigated using spectral shaping at 100 kV (Sn 100 kV) for the assessment of osteolytic lesions in patients with multiple myeloma. Thirty consecutive patients with multiple myeloma who underwent a WBLDCT on a third-generation dual-source CT (DSCT) (Sn 100 kV, ref. mAs: 130) were retrospectively chosen. They evaluated objective and subjective image quality, radiation exposure, and the frequency of osteolytic lesions. The results provided evidence that sufficient image quality for the portrayal of osteolytic lesions can be obtained with WBLDCT with Sn 100 kV while reducing the radiation dose by approximately 74%.