Whole-body MRI vs an FDG-PET/CT-based reference standard for staging of paediatric Hodgkin lymphoma: A prospective multicentre study
European Radiology Sep 08, 2020
Spijkers S, Littooij AS, Kwee TC, et al. - In this prospective, multicentre, international study among children with Hodgkin lymphoma (HL), the concordance of whole-body magnetic resonance imaging (WB-MRI) and an FDG-PET/CT (18F-Fluorodeoxyglucose positron emission tomography/computed)-based reference standard was evaluated for the initial staging in this pediatric patient population. Participants had newly diagnosed HL and underwent WB-MRI and FDG-PET/CT at staging. Overall 68 children were examined. For disease stage, good inter-observer agreement between WB-MRI DWI (diffusion-weighted imaging) readers was found. As per findings, an excellent agreement with the FDG-PET/CT-based reference standard was displayed by WB-MRI DWI. Improved staging agreement was achieved by the addition of DWI to the WB-MRI protocol.
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