Wardlaw JM, et al. - Researchers planned this study to evaluate factors correlated with white matter hyperintensity (WMH) change in a large cohort after observing obvious WMH shrinkage 1 year after minor stroke in several participants in a longitudinal study. With potentially better clinical and brain tissue outcomes, some WMH could regress after a minor stroke. The role of risk factor control required verification. Interstitial fluid alterations could account for some WMH reversibility, offering potential intervention targets.