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Which intervention is better for malaria vector control: Insecticide mixture long-lasting insecticidal nets or standard pyrethroid nets combined with indoor residual spraying?

Malaria Journal Evidence based | Aug 25, 2017

Ngufor C, et al. – Authors aimed at assessing the efficacy of Interceptor G2 long–lasting insecticidal net (LN), a newly developed LN treated with a mixture of chlorfenapyr (a pyrrole) and alpha–cypermethrin (a pyrethroid), in comparison to a combined chlorfenapyr indoor residual spraying (IRS) and Interceptor LN (a standard alpha–cypermethrin LN) intervention in experimental huts in Cove Southern Benin, against wild, free–flying, pyrethroid–resistant Anopheles gambiae s.l. They also made a direct comparison with a pyrethroid–only net (Interceptor LN) alone and chorfenapyr IRS alone. The use of chlorfenapyr and alpha–cypermethrin together as a mixture on nets (Interceptor G2 LN) or a combined chlorfenapyr IRS and pyrethroid LN intervention seemed to provide improved control of pyrethroid–resistant malaria vectors by inducing significantly higher levels of mortality through the chlorfenapyr component and providing personal protection through the pyrethroid component. Both strategies were similar regarding their potential to improve the control of malaria transmitted by pyrethroid resistant mosquito vectors.
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