Bennell KL, Nelligan RK, Kimp AJ, et al. - Researchers undertook a participant- and assessor-blinded randomized controlled trial with people suffering from medial knee OA and co-morbid obesity, to compare two exercise programs for their effectiveness in this patient group. Interventions included home-based non-weight bearing (NWB) quadriceps strengthening or weight bearing (WB) functional exercise for 12 weeks. The alteration in overall knee pain (numeric rating scale, range 0-10) and problem with physical function (Western Ontario and McMaster Universities Osteoarthritis Index, 0-68) over 12 weeks were considered as primary outcomes, and secondary outcomes were: other pain measures, physical function, quality-of-life, global changes, physical performance, and lower-limb muscle strength. The observed improvement in primary outcomes of pain and function with both exercise types was similar, and both can be advised for individuals with knee OA and obesity. Owing to fewer adverse events related to WB exercise and its potential additional benefits on some secondary outcomes, WB exercise may be preferred.