Turgeon GA, et al. - Via comparing survival outcomes according to the criteria of the European Organization for Research and Treatment of Cancer (EORTC), PERCIST 1.0, the Peter Mac metabolic visual criteria, and the Deauville criteria, researchers analyzed the optimal methodology for defining response with ¹⁸F-FDG PET after curative-intent chemoradiation for non–small cell lung cancer (NSCLC). Between 2004 and 2016, three prospective trials of chemoradiation for NSCLC involving baseline and posttreatment ¹⁸F-FDG PET/CT imaging were conducted. They categorized responses as a complete metabolic response (CMR), partial metabolic response, stable metabolic disease, or progressive metabolic disease. Outcomes revealed that Peter Mac and Deauville have shown better fit than EORTC and PERCIST and have made a better distinction between CMR and non-CMR. According to findings, all four response criteria were highly predictive of overall survival, but visual criteria exhibited greater interobserver agreement and greater discrimination between CMR and non-CMR, highlighting the significance of visual evaluation to recognize radiation pneumonitis, lung configuration changes, and response patterns.