Bouxom H, et al. - Researchers determined the activity of 18 non-carbapenem antibiotics on 100 ESBL-producing Escherichia coli (ESBL-Ec) and 50 ESBL-producing Klebsiella pneumoniae (ESBL-Kp) isolated from urinary tract infections and bacteremia in 2016. E. coli that produced ESBL were found to be fully susceptible to ertapenem and ceftazidime-avibactam and a great majority were susceptible to fosfomycin (98%), piperacillin-tazobactam (97%), amikacin (97%) and nitrofurantoin (96%). On ESBL producing K. pneumoniae, ceftazidime-avibactam was fully active, however, ertapenem, amikacin and mecillinam were active on 98, 94 and 90% of isolates, respectively. Ceftazidime-avibactam was identified as the most efficient alternative.