Houskamp DJ, et al. - The present study was conducted to develop the association between depth of resection of the medial tibial plateau and mean maximum load to failure. Researchers conducted medial tibial resections from 2 to 10 mm in 25 standardized fourth-generation Sawbones composite tibias (Sawbones, Vashon Island, Washington). They applied a metal-backed tibial component with a 9-mm polyethylene bearing. The evidence showed that medial tibial resections beyond 5.82 mm produced a significantly lower mean load to failure applying a quadratic curve model in this biomechanical model. It was noted that resections from 2 to 6 mm exhibited no significant alterations in mean load to failure. After a medial unicompartmental knee arthroplasty, evaluation of the tibial resection depth at which the mean load to failure significantly reduces is clinically relevant as this depth may elevate the risk of periprosthetic fracture.