Roberts SA, Gillespie TC, Shui AM, et al. - Whether and how postoperative weight change is associated with breast cancer–related lymphedema (BCRL), was investigated in this cohort study with 1161 women. Participants had unilateral breast surgery for breast cancer from 2005 to 2020, and had prospective screening for BCRL (defined as a relative volume alteration of the ipsilateral arm of ≥10% at least 3 months post-surgery). Development of BCRL occurred in 92 patients (7.9%). There was no protective impact of net weight loss, vs net weight gain, from baseline to last follow-up on the development of BCRL. Experts concluded that weight loss may be advised as a component of an individualized lifestyle management program for overall health but weight loss alone may not bring about a reduction in the risk of developing BCRL.