Weight gain after curative parathyroidectomy predicts increase in bone mineral density in patients with symptomatic primary hyperparathyroidism
Clinical Endocrinology Apr 18, 2020
Pal R, Arya AK, Aggarwal A, et al. - Researchers performed a retrospective study to measure the magnitude of improvement in bone mineral density (BMD) after curative surgery in patients with symptomatic primary hyperparathyroidism (PHPT) and dissect out the possible clinical and biochemical parameters predicting the BMD rise. The sample consisted of symptomatic PHPT patients undergoing surgery from August 2016 to July 2018. The research included patients with pre and postoperative biochemical cure (at least 1 year after surgery) dual energy x‐ray absorptiometry scans performed. Sixty-three patients were included in the study (M:F = 2:5; mean age = 44.8 years) after exclusion. the median percent change in BMD at lumbar spine, total hip, femoral neck and one‐third distal radius (forearm) was 6.5%, 7.0%, 8.1% and 6.9%, respectively, at a median interval of 15 months. In patients with symptomatic PHPT, curative surgery improves BMD at all sites. Post surgery weight gain can be used as a good clinical indicator of BMD increase.
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