Cook NR, et al. - Researchers assessed mortality, randomized weight loss and observed weight change among all the participants of the Trials of Hypertension Prevention (TOHP) with high baseline weight. TOHP were performed on individuals aged 30-54 years with high normal blood pressure (BP). These individuals randomly received weight loss, usual care or other intervention over 18 months (TOHP I) or 3-4 years (TOHP II), with average 23-year mortality follow-up. Death of 227 of 2,964 participants was reported, with no intervention difference. A direct association was seen between weight change and mortality among 3,828 high-weight participants. Findings were suggestive of a long-term beneficial effect of presumed intentional weight loss on mortality.