Bohlega B, Zahedi A, Tomlinson G, et al. - This retrospective cohort study was conducted to perform comparison between a weight‐based dosing method of starting thyroxine vs a fixed‐dose method in newly diagnosed females with subclinical hypothyroidism during pregnancy. Women that received treatment on the basis of prepregnancy weight and those that were administered a fixed dose of 50 mcg/day, were identified. Overall, this study included 393 women: 252 managed using a fixed‐dose approach; 141 managed based on prepregnancy weight. An increase in the odds of reaching the target TSH range within 4–8 weeks was shown to be conferred by a weight‐based treatment strategy for women with newly diagnosed subclinical hypothyroidism during pregnancy. Clinicians caring for these females are advised to consider this strategy when initiating treatment during pregnancy.