Liebowitz MR, et al. - This preliminary trial was performed to compare the efficacy and safety of vortioxetine vs placebo in major depressive disorder (MDD) comorbid with social anxiety disorder (SAD). For patients with MDD comorbid with SAD, vortioxetine appeared safe and effective, with robust effect sizes on dimensional measures of both depression and social anxiety, but failure to separate from placebo on the primary outcome measure of composite responder rate.